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transmission disequilibrium test : ウィキペディア英語版
transmission disequilibrium test
The transmission disequilibrium test (TDT) was proposed by Spielman, McGinnis and Ewens (1993) as a family-based association test for the presence of genetic linkage between a genetic marker and a trait. It is an application of McNemar's test.
A specificity of the TDT is that it will detect genetic linkage only in the presence of genetic association.
While genetic association can be caused by population structure, genetic linkage will not be affected, which makes the TDT robust to the presence of population structure.
== The case of trios: one affected child per family ==


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